J. Schumacher

Acute kidney injury-induced circulating TNFR1/2 elevations correlate with persistent kidney injury and progression to fibrosis

This study shows that acute kidney injury (AKI) increases circulating TNFR1/2 levels, which correlate with kidney injury severity and progression to fibrosis, particularly through extracellular vesicle-bound forms.

Human Th17- and IgG3-associated autoimmunity induced by a translocating gut pathobiont

This study shows that the gut pathobiont Enterococcus gallinarum induces human Th17 and IgG3 autoantibody responses linked to disease activity in autoimmune patients.

Arabidopsis thaliana BBX14 is a target of GLK1 and involved in high-light acclimation, photomorphogenesis and GUN-type retrograde signaling

The first archaeal PET-degrading enzyme belongs to the feruloyl-esterase family

The paper identifies and characterizes PET46, an archaeal feruloyl esterase capable of degrading PET, expanding the known diversity of PET-hydrolyzing enzymes.

INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA

This study shows that IGF-1 reduces coronary atherosclerosis and promotes stable plaque features in FH pigs, with spatial transcriptomics revealing potential mechanistic insights.

Diversity-induced plant history and soil history effects modulate plant responses to global change

The paper investigates how plant and soil history affect plant responses to global change by testing offspring from different diversity communities under various environmental conditions.

A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data

The paper reconstructs 3D gene expression patterns in a floral meristem using single-nuclei RNA-seq and spatial reconstruction to study cell identity and organ patterning.

An endocrine-hepato-muscular metabolic cycle links skeletal muscle atrophy and hyperglycemia in type 2 diabetes

This study identifies an endocrine-hepato-muscular metabolic cycle linking hyperglycemia and skeletal muscle atrophy in type 2 diabetes through dysregulated alanine metabolism and ALT enzyme activity.

A multiplexed work-flow for absolute quantification of Klebsiella oxytoca Nif proteins

This study develops a high-throughput pipeline to quantify all twenty Nif proteins in Klebsiella oxytoca using MRM-MS and QconCAT standards, revealing temporal regulation and abundance disparities.

Molecular origins of transcriptional heterogeneity in diazotrophic K. oxytoca

The paper identifies molecular sources of transcriptional heterogeneity in nitrogen fixation genes of Klebsiella oxytoca using single-cell RNA-FISH and stochastic modeling.

Analog nitrogen sensing in Escherichia coli enables high fidelity information processing

This study measures proteomic and metabolomic responses in E. coli to quantify the information capacity of its nitrogen sensing network, finding it can transmit up to 9 bits of information.