ImmunologybioRxiv
Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction
H. Sid, T. von Heyl, S. Schleibinger…·B. Schusser
This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.
DOI 10.3389/fimmu.2025.1680791