L. Vervelde

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.

Disentangling the Innate Immune Responses of Intestinal Epithelial Cells and Lamina Propria Cells to Salmonella Typhimurium Infection in Chickens

This study compares innate immune responses in 2D and 3D chicken enteroids infected with Salmonella Typhimurium, showing that 3D models better mimic in vivo responses due to the presence of lamina propria cells.

Novel technology to develop non-transmissible live influenza virus vaccines through alterations in M2/M42 ion channel expression

This paper develops non-transmissible live influenza virus vaccines by altering M2/M42 ion channel expression, showing they protect against H5 HPAIV without transmission.

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

Kinetics of the immune response to Eimeria maxima in relatively resistant and susceptible chicken lines

This study compares immune response kinetics between two chicken lines infected with Eimeria maxima, finding early cytokine responses in resistant chickens.

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

This paper shows that mutating the PA-X gene in influenza A virus reduces pathogenicity in chicken embryos and increases HA yield in vaccine reassortant viruses.