Author

M. M. Zarou

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Dawson· 1 shared A. Ianniciello· 1 shared A. Vazquez· 1 shared D. Sarnello· 1 shared D. Sumpton· 1 shared K. Dunn· 1 shared K. M. Rattigan· 1 shared M. Copland· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Dawson

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1 paper

Recent·Most cited

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing

M. M. Zarou, K. M. Rattigan, D. Sarnello, A. Dawson, A. Ianniciello, K. Dunn, M. Copland, D. Sumpton, A. Vazquez, V. Helgason

The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.

bioRxiv · Dec 21, 2022 · PreprintCancer Biology