Author
A. Vazquez
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2017-2024 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 8 mutual co-author links10 papers
Recent·Most cited
Differential roles of putative arginine fingers of AAA+ ATPases Rvb1 and Rvb2
J. L. Warnock, J. A. Ball, S. M. Najmi, M. Henes, A. Vazquez, S. Koshnevis, H.-J. Wieden, G. L. Conn, H. Ghalei
This study identifies distinct roles of arginine fingers in Rvb1 and Rvb2 ATPases, showing how changes in their active sites affect catalytic activity, protein interactions, and cellular functions.
bioRxiv · May 13, 2024 · PreprintBiochemistry
Requirements for efficient endosomal escape by designed mini-proteins
J. Giudice, D. D. Brauer, M. Zoltek, A. Vazquez, M. J. S. Kelly, A. Schepartz
This paper identifies the requirements for efficient endosomal escape by ZF5.3, a mini-protein, showing pH-induced unfolding and lipid-BMP interaction are critical for its function.
bioRxiv · Apr 5, 2024 · PreprintBiochemistry
MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
S. C. Massoni, N. J. Evans, I. Hantke, C. Fenton, J. H. Torpey, K. M. Collins, E. M. Krysztofinska, J. H. Muench, A. Thapaliya, S. Martinez-Lumbreras, S. H. Martin, C. Slater, X. Wang, R. Fekade, S. Obwar, , A. H. Camp
This study identifies MdfA as a ClpC adaptor protein in Bacillus subtilis that promotes spore metabolic dormancy by inducing ClpCP-mediated degradation of metabolic enzymes.
bioRxiv · Mar 2, 2024Microbiology
Rewiring of the host cell metabolome and lipidome during lytic gammaherpesvirus infection is essential for infectious virus production
S. A. Clark, A. Vazquez, K. Furiya, M. K. Splattstoesser, A. K. Bashmail, H. Schwartz, M. Russell, S.-J. Bhark, O. K. Moreno, M. McGovern, E. R. Owsley, T. A. Nelson, E. Sanchez, T. Delgado
This study identifies metabolic rewiring in host cells during gammaherpesvirus infection, showing that glucose, glutamine, and lipid metabolism are essential for viral production.
bioRxiv · Jan 30, 2023Microbiology
Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
M. M. Zarou, K. M. Rattigan, D. Sarnello, A. Dawson, A. Ianniciello, K. Dunn, M. Copland, D. Sumpton, A. Vazquez, V. Helgason
The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.
bioRxiv · Dec 21, 2022 · PreprintCancer Biology
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
N. Kiweler, C. Delbrouck, V. I. Pozdeev, L. Neises, L. Soriano-Baguet, K. Eiden, F. Xian, M. Benzarti, L. Haase, E. Koncina, M. Schmoetten, C. Jaeger, M. Z. Noman, A. Vazquez, B. Janji, , J. Meiser
This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.
Nature Communications · May 16, 2022Peer-reviewedCancer Biology
Oxygen dependent mitochondrial formate production and the reverse Pasteur effect
The paper shows oxygen stimulates mitochondrial formate production, which increases glycolysis, contradicting the Pasteur effect and suggesting a reverse Pasteur effect in mammalian cells.
bioRxiv · Apr 10, 2020 · PreprintBiochemistry
Formate induces a metabolic switch in nucleotide and energy metabolism
K. Oizel, J. Tait-Mulder, J. Fernandez-de-Cossio-Diaz, M. Pietzke, H. Brunton, S. Dhayade, D. Athineos, S. Lilla, G. Rodriguez Blanco, D. Sumpton, G. M. Mackay, K. Blyth, S. Zanivan, J. Meiser, A. Vazquez
This study shows formate induces a metabolic switch increasing adenine nucleotides, glycolysis, and repressing AMPK, with implications for cancer metabolism.
bioRxiv · Aug 16, 2019Biochemistry