Author

K. M. Rattigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Dawson· 1 shared A. Ianniciello· 1 shared A. S. M. Magee· 1 shared A. Vazquez· 1 shared B. J. P. Huntly· 1 shared C. Mappereley· 1 shared C. Philippe· 1 shared D. Sarnello· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Dawson

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 21, 2022

Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing

M. M. Zarou, K. M. Rattigan, D. Sarnello…·V. Helgason

The paper shows that inhibiting mitochondrial folate metabolism drives differentiation in CML cells via mTORC1 and purine sensing, and enhances the efficacy of imatinib in reducing therapy-resistant LSCs.

DOI 10.1101/2022.12.21.521404

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivMay 16, 2022

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

K. Woodley, L. S. Dillingh, G. Giotopoulos…·P. Gallipoli

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

DOI 10.1038/s41467-023-37652-0

humanexperimental assay

𝕏 PostBluesky