ImmunologybioRxiv
Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV
N. Vabret, V. Najburg, A. Solovyov…·A. Komarova
This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.
DOI 10.1016/j.isci.2022.104599