F. Tangy

Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

Respiratory Syncytial virus NS1 protein targets the transactivator binding domain of MED25

This paper identifies the interaction between RSV NS1 and MED25's ACID domain, showing NS1 competes with ATF6 to inhibit innate immune gene transcription.

HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes

This study shows HIV-1 spreads between T lymphocytes via extracellular matrix (ECM)-clustered viral particles, enhancing transmission efficiency and resistance to antiretroviral treatment and antibodies.

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection

This study shows that TAX1BP1 depletion enhances innate immune responses during RSV infection, suggesting it as a potential antiviral target.

A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice

Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP/p53 Protein Complex

The paper identifies p65/iASPP/p53 protein complex as a specific interaction partner of measles virus protein C, revealing its role in regulating cell death and innate immunity pathways.

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

This study identifies RIG-I and PKR as key mediators of the pro-inflammatory response to YFV in hepatocytes, showing that stress granules are not required for cytokine induction.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

This study shows that YFV-17D replicates inefficiently in Aedes aegypti midgut and fails to disseminate, unlike a clinical isolate, due to midgut barriers.