H. Varet

MAPPING CHANGES OF MIRNA-MRNA NETWORKS IN LEISHMANIA-INFECTED MACROPHAGES PREDICTS REGULATORY MIRNA-TF LOOPS AS NOVEL TARGETS OF PARASITE IMMUNE SUBVERSION

Inhibition of the macrophage demethylase LSD1 reverses Leishmania amazonensis-induced transcriptomic changes and causes a decrease in parasite load

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

Transcriptome profiling of human colonic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.

This study profiles the transcriptome of human colonic cells exposed to SGG, showing it induces stronger transcriptional changes in cancerous HT29 cells than in normal FHC cells, with significant ER stress and UPR activation.

Leishmania amazonensis controls macrophage-regulated cell death to establish chronic infection in vitro and in vivo

This study shows Leishmania amazonensis suppresses macrophage-regulated cell death pathways to promote chronic infection in vitro and in vivo.

The m6A reader IGF2BP2 directs immune-metabolic reprogramming in Leishmania amazonensis-infected macrophages

This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.

Recognition of copy-back defective interfering rabies virus genomes by RIG-I triggers the antiviral response against vaccine strains

This study shows that pathogenic RABV strains lack defective interfering genomes, leading to weak antiviral responses, while attenuated vaccine strains release 5cb DI genomes that enhance RIG-I-mediated IFN signaling and antiviral activity.

Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness

This study shows that larval exposure to specific bacteria in mosquitoes alters lipid metabolism, affecting adult survival and fitness.

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

The CovR regulatory network drives the evolution of Group B Streptococcus virulence

This study characterizes the CovR regulatory network in Group B Streptococcus, showing its role in virulence gene regulation and strain-specific adaptations.

Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides.

The paper shows indole, induced by sublethal tobramycin, increases persistence to aminoglycosides in V. cholerae via RaiA-mediated ribosome storage.

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence.

This study identifies and characterizes a second peroxide stress regulator, PerRB, in Leptospira, showing that PerRA and PerRB cooperatively regulate virulence through oxidative stress adaptation.

Bacteriocin production in Streptococcus gallolyticus by a complex 4-component regulatory system with activator and anti-activator activities

This paper identifies a 4-component regulatory system in Streptococcus gallolyticus that controls gallocin production through activator and anti-activator proteins.

Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.

Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder

The paper identifies two distinct bladder macrophage subsets, shows their differential responses to infection, and demonstrates their impact on immune outcomes.

The adaptive transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress

This study identifies the adaptive transcriptional response of Leptospira to peroxide stress, revealing key defense mechanisms against oxidative stress during infection.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

Tudor-SN promotes early replication of dengue virus in the Aedes aegypti midgut

This study identifies Tudor-SN as a proviral factor that promotes early dengue virus replication in Aedes aegypti midgut cells.

Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

This paper demonstrates that Cryptococcus neoformans can enter a viable but non-culturable state under specific in vitro conditions, characterized by reduced metabolism and reactivation potential.

Leishmania targets the macrophage epigenome and dampens the NF-κB/NLRP3- mediated inflammatory response

This study shows Leishmania amazonensis modulates macrophage epigenetics to suppress NF-κB and NLRP3 inflammasome activation, aiding parasite survival.

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae.

This study shows that ribosomal protein gene location affects bacterial growth rate and macromolecular crowding in Vibrio cholerae.

Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages

This study identifies genes in Mycobacterium abscessus that enhance survival in macrophages by analyzing transcriptomes in amoebae and macrophages.