PKR and the Integrated Stress Response drive immunopathology caused by ADAR1 mutation
M. Maurano, J. M. Snyder, C. Connelly, J. Henao-Mejia, C. Sidrauski, D. B. Stetson
This study shows that PKR and the integrated stress response drive immunopathology in ADAR1 mutation models, and an ISR inhibitor prevents disease.
bioRxiv · Nov 30, 2020 · PreprintImmunology