This study demonstrates that immunomodulatory porous scaffolds improve vascular graft healing by promoting endothelialization and transmural cellular infiltration compared to standard PTFE grafts.

Biomaterials · Sep 1, 2025Peer-reviewedBioengineering

Fluoxetine promotes immunometabolic defenses to mediate host-pathogen cooperation during sepsis

R. M. Gallant, J. M. Snyder, J. S. Ayres

This study shows fluoxetine protects against sepsis by increasing IL-10, which prevents metabolic issues in the heart.

bioRxiv · Nov 18, 2023 · PreprintImmunology

Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection

J. Tisoncik-Go, C. Stokes, L. Whitmore, D. J. Newhouse, K. Voss, A. Gustin, C.-J. Song, E. Smith, J. Stencel-Baerenwald, E. D. Parker, J. M. Snyder, D. Shaw, L. Rajagopal, R. P. Kapur, K. A. Waldorf, M. Gale

This study investigates the effects of prenatal Zika virus exposure on fetal myelin structure and oligodendrocyte maturation in pigtail macaques, finding disruptions in myelin formation and gene expression related to oligodendrocyte development.

bioRxiv · Oct 11, 2023Immunology

Age-dependent roles of cardiac remodeling in sepsis defense and pathogenesis

K. K. Sanchez, J. L. McCarville, S. J. Stengel, J. M. Snyder, A. E. Williams, J. S. Ayres

This study shows that age affects disease tolerance mechanisms in sepsis, with a cardioprotective pathway in young mice causing heart damage in older mice.

bioRxiv · Mar 14, 2023 · PreprintImmunology

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

A. Bitto, A. S. Grillo, I. B. Stanaway, B. M. G. Nguyen, K. Ying, H. Tung, K. Smith, N. Tran, G. Velikanje, S. Urfer, J. M. Snyder, E.-B. Kayser, L. Wang, D. L. Smith, J. W. Thompson, , M. Kaeberlein

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry

ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunity

J. H. Maltbaek, J. M. Snyder, D. B. Stetson

This study identifies ABCC1/MRP1 as an ATP-dependent cGAMP exporter that modulates cGAS-STING signaling and type I interferon production.

bioRxiv · Dec 3, 2021 · PreprintImmunology

PKR and the Integrated Stress Response drive immunopathology caused by ADAR1 mutation

M. Maurano, J. M. Snyder, C. Connelly, J. Henao-Mejia, C. Sidrauski, D. B. Stetson

This study shows that PKR and the integrated stress response drive immunopathology in ADAR1 mutation models, and an ISR inhibitor prevents disease.

bioRxiv · Nov 30, 2020 · PreprintImmunology

Neutrophils Mediate Kidney Inflammation Following Acute Skin Exposure to UVB Light

S. Skopelja-Gardner, J. Tai, X. Sun, L. Tanaka, J. A. Kuchenbecker, J. M. Snyder, P. Kubes, T. Mustelin, K. B. Elkon

This study shows UVB light exposure leads to neutrophil migration to the kidney, causing inflammation and injury, with implications for systemic lupus flares.

bioRxiv · May 25, 2020Immunology

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

R. A. Miller, D. E. Harrison, D. B. Allison, M. Bogue, V. Diaz, E. Fernandez, A. Galecki, W. T. Garvey, N. Kumar, M. A. Javors, W. C. Ladies, F. Macchiarini, J. Nelson, P. Reifsnyder, N. A. Rosenthal, , R. Strong

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

bioRxiv · May 23, 2020 · PreprintPathology