Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome
K. Khanna, H. Yan, M. Mehra, N. Rohatgi, G. Mbalaviele, R. Faccio
This study identifies Tmem178 as a negative regulator of IL-1β production by inhibiting the NLRP3 inflammasome in macrophages, with implications for sJIA and CSS.
bioRxiv · Mar 7, 2023Immunology