G. Mbalaviele

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

This study shows doxorubicin causes bone loss via inflammasome activation, leading to pyroptosis and NETosis, and identifies AIM2 and NLRP3 as key mediators.

Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome

This study identifies Tmem178 as a negative regulator of IL-1β production by inhibiting the NLRP3 inflammasome in macrophages, with implications for sJIA and CSS.

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

NEK7 activates the NLRP1 Inflammasome

This study shows NEK7 activates NLRP1 inflammasome independently of NLRP3, affecting IL-1β maturation in Nek7-deficient cells.

Glutamine metabolism modulates chondrocyte inflammatory response

This study shows that glutamine metabolism in chondrocytes influences inflammatory responses and autophagy, with glutamine deprivation reducing inflammation by inhibiting NF-κB.

Fracture healing is delayed in the absence of gasdermin signaling

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

Inhibition of the NLRP3 inflammasome prevents ovarian aging

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.