K. Khanna

A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

The paper identifies BCL6's role in maintaining CX3CR1+ CD4+ T cells during helminth infections through fate-mapping and single-cell RNA-sequencing.

Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome

This study identifies Tmem178 as a negative regulator of IL-1β production by inhibiting the NLRP3 inflammasome in macrophages, with implications for sJIA and CSS.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

Subcellular Organization of Viral Particles During Maturation of Nucleus-Forming Jumbo Phage

The paper visualizes the subcellular organization of mature viral particles in nucleus-forming jumbo phages, revealing a structured assembly process called phage bouquets.

Rapid Kinetic Fingerprinting of Single Nucleic Acid Molecules by a FRET-based Dynamic Nanosensor

This paper introduces iSiMREPS, a method for rapid, single-molecule detection of miRNAs and ctDNAs with high specificity and sensitivity, achieving detection in 10 seconds.

Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE-2 in vitro

Thiol drugs inhibit SARS-CoV-2 infection in vitro and reduce lung injury in vivo, supporting their potential as COVID-19 treatments.

Selective transport of fluorescent proteins into the phage nucleus

The paper investigates nuclear transport in phage infection systems, finding that GFPmut1 can be selectively transported into the {Phi}KZ phage nucleus, with specific amino acid residues identified for this process.

Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

This study identifies lung macrophages that kill helminths by depleting arginine through differential activation of recruited monocyte-derived alveolar macrophages.

Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

This study shows that during Bacillus subtilis sporulation, the cell division machinery is asymmetrically localized, leading to different cell fates.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.

This study shows Adhatoda Vasica extract reduces hypoxia-induced mitochondrial dysfunction and inflammation in asthma models, offering potential for treating severe steroid-resistant asthma.

The molecular architecture of engulfment during Bacillus subtilis sporulation

This study uses cryo-electron tomography to visualize Bacillus subtilis sporulation, revealing new insights into the engulfment process and the role of the SpoIIDMP complex in membrane migration.

Simvastatin mediates inhibition of exosome synthesis, localization, and secretion via multicomponent interventions.

This study shows simvastatin reduces exosome secretion by targeting cholesterol pathways in vitro and in vivo.