Afucosylated maternal anti-dengue IgGs are a biomarker for susceptibility to dengue disease in their infants
N. K. Thulin, R. C. Brewer, R. Sherwood, S. Bournazos, K. G. Edwards, N. S. Ramadoss, J. K. Taubenberger, M. Memoli, P. Jagannathan, S. Zhang, D. H. Libraty, T. T. Wang
The paper identifies afucosylation of maternal anti-dengue IgGs as a biomarker for infant susceptibility to symptomatic dengue infections and explains its mechanism involving Fc{gamma}RIIIa-mediated enhancement of viral replication.
bioRxiv · Mar 6, 2019 · PreprintImmunology