P. Jagannathan

Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

The paper shows that repeated Plasmodium infection leads to epigenetic changes in innate immune cells, which suppress inflammation and confer long-term disease tolerance in Ugandan children.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker

The paper designs and tests novel viral microbial source tracking markers based on ToBRFV genomes, finding they are sensitive, specific, and more prevalent in human stool and wastewater than existing markers.

Atypical B cells consist of subsets with distinct effector functions

The paper identifies three distinct subsets of atypical B cells with unique transcriptional and functional profiles in individuals with chronic Plasmodium falciparum exposure.

Age dependent changes in circulating Tfh cells influence the development of functional antibodies to malaria in children.

The paper examines age-related changes in Tfh cells and their impact on antibody development against malaria in children, finding age-dependent shifts in Tfh cell subsets and antibody responses.

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

FcRn, but not FcgRs, drives maternal-fetal transplacental transport of human IgGantibodies

This study shows that FcRn, not FcγRs, is responsible for maternal-fetal transport of IgG antibodies, suggesting FcRn engineering could improve antibody transfer to the fetus.

Afucosylated maternal anti-dengue IgGs are a biomarker for susceptibility to dengue disease in their infants

The paper identifies afucosylation of maternal anti-dengue IgGs as a biomarker for infant susceptibility to symptomatic dengue infections and explains its mechanism involving Fc{gamma}RIIIa-mediated enhancement of viral replication.