J. K. Taubenberger

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

Archival influenza virus genomes from Europe reveal genomic and phenotypic variability during the 1918 pandemic

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

Afucosylated maternal anti-dengue IgGs are a biomarker for susceptibility to dengue disease in their infants

The paper identifies afucosylation of maternal anti-dengue IgGs as a biomarker for infant susceptibility to symptomatic dengue infections and explains its mechanism involving Fc{gamma}RIIIa-mediated enhancement of viral replication.

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

This paper shows that mutating the PA-X gene in influenza A virus reduces pathogenicity in chicken embryos and increases HA yield in vaccine reassortant viruses.