Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation
J. von Ehr, L. Oberstrass, E. Yazgan, L. I. Schnaubelt, N. Bluemel, F. McNicoll, J. E. Weigand, K. Zarnack, M. Mueller-McNicoll, S. M. Korn, A. Schlundt
This study defines Arid5a's DNA and RNA-binding preferences using biochemical and high-throughput methods, showing that disordered regions modulate its nucleic acid interactions and gene regulation.
bioRxiv · Feb 29, 2024Biochemistry