C. de Heus

Morpho-functional characterization of the endo-lysosomal system by high-throughput correlative light-electron microscopy

The paper uses correlative light-electron microscopy to characterize the ultrastructural distribution of endosomal proteins at endogenous levels.

Bimodal Endocytic Probe for Three-Dimensional Correlative Light and Electron Microscopy

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.

Correlative Organelle Microscopy: fluorescence guided volume electron microscopy of intracellular processes

This paper introduces a targeted volume-CLEM pipeline that enables high-precision 3D correlation between fluorescence and electron microscopy data, enhancing throughput and enabling study of rare cellular events.

An Organoid for woven Bone

This study develops a 3D in vitro organoid model of woven bone formation using human bone marrow stromal cells, demonstrating osteoblast and osteocyte co-culture and mineralization.

A paralog-specific role of the COPI pathway in the neuronal differentiation of murine pluripotent cells

This study identifies a specific role for γ1-COP in neurite outgrowth during neuronal differentiation of mouse pluripotent cells, while showing functional redundancy between γ1-COP and γ2-COP.

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.