RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis.
M. Naszai, K. Bellec, Y. Yu, A. Roman Fernandez, E. Sandilands, J. Johansson, A. D. Campbell, J. C. Norman, O. J. Sansom, D. Bryant, J. B. Cordero
This study shows RAL GTPases activate EGFR/MAPK signaling in intestinal stem cells, promoting proliferation and tumorigenesis, but are independent of oncogenic RAS.
bioRxiv · Oct 7, 2020 · PreprintCancer Biology