The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain
J. C. Sanchez, L. Zhang, S. Evoli, N. J. Schnicker, M. Nunez-Hernandez, L. Yu, J. Wereszczynski, M. A. Pufall, C. A. Musselman
This study identifies the DNA specificity and structural basis of BRG1's composite domain using SELEX-seq, NMR, and modeling, showing how cancer mutations alter DNA binding.
bioRxiv · Nov 25, 2019Biochemistry