N. J. Schnicker

Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

A double-ring of human RAD52 remodels replication forks restricting fork reversal

The paper shows human RAD52 forms a double-ring structure around stalled replication forks, remodeling them via DNA strand exchange to prevent reversal by SMARCAL1.

A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

Structure and mechanism of LARGE1 matriglycan polymerase

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

Structural basis for APE1 processing DNA damage in the nucleosome

This study reveals how APE1 processes DNA damage in nucleosomes by bending DNA to access AP sites, with efficiency depending on site exposure.

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.

The paper identifies ANTH domains in CALM, HIP1R, and Sla2 that bind ubiquitin, contributing to clathrin-mediated endocytosis of ubiquitinated membrane proteins.

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

The Molecular Basis of Specific DNA Binding by the BRG1 AT-hook and Bromodomain

This study identifies the DNA specificity and structural basis of BRG1's composite domain using SELEX-seq, NMR, and modeling, showing how cancer mutations alter DNA binding.