M. O. Bernabeu

Effect of vessel compression on blood flow in microvascular networks: implications for tumour tissue hypoxia

This study numerically examines how vessel compression in microvascular networks affects red blood cell transport, finding reduced average haematocrit and increased heterogeneity.

Generating fast-twitch myotubes in vitro using an optogenetic-based, quantitative contractility assay

This study uses an optogenetic contractility assay to generate fast-twitch myotubes in vitro, showing increased contractile function and fiber type shift.

Red blood cell lingering modulates hematocrit distribution in the microcirculation

This study quantifies how red blood cell lingering at microvascular bifurcations affects hematocrit distribution and shows its correlation with RBC membrane rigidity and bifurcation geometry.

Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media

This study models red blood cell dynamics in extravascular tissues as disordered porous media, finding that structural disorder increases apparent viscosity and promotes RBC homogeneity.

An in vitro - agent based modelling approach to optimisation of culture medium for generating muscle cells

The paper uses an agent-based model to predict optimal culture media for muscle cell generation, finding trade-offs between cell quantity and quality.

Vessel compression biases red blood cell partitioning at bifurcations in a haematocrit-dependent manner: implications for tumour blood flow

This study uses a computational model to show vessel compression affects red blood cell partitioning at bifurcations in a haematocrit-dependent way, impacting tumour oxygenation.

Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation

The paper investigates how abnormal vascular morphology affects haematocrit distribution and tissue oxygenation in tumours, introducing a metric λ to monitor anti-angiogenic treatment efficacy.

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling

This paper presents an agent-based model to study how endothelial cells integrate flow and collective cues to preserve vessel bifurcations during angiogenic remodelling, finding that both cues must be balanced for stability.