H. M. Byrne

This paper introduces three extensions to the cross-pair correlation function for spatial analysis of multiplex imaging data, demonstrating their application on synthetic and biological datasets.

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

This paper develops a DNA-structured mathematical model to predict how cyclic hypoxia affects cell-cycle progression, showing that prolonged re-oxygenation slows proliferation while short cycles inhibit it.

The paper investigates how abnormal vascular morphology affects haematocrit distribution and tissue oxygenation in tumours, introducing a metric λ to monitor anti-angiogenic treatment efficacy.

The paper uses a phenotype-structured model to show how fluctuating oxygen levels affect cell population dynamics and competitive advantage through phenotypic variation rates.

This study shows that efferocytosis in macrophages concentrates harmful substances, leading to increased accumulation of exogenous and endogenous materials within the population.

This paper develops a mathematical model of lipid accumulation in macrophages within atherosclerotic plaques and shows how lipid distribution and inflammation can be influenced by macrophage behavior and parameters.

This paper introduces a non-linear age-structured population model to explain the two-phase proliferation observed in scratch assays, showing that resource concentration regulates the transition between phases.

This paper develops a 3D mathematical model of corneal angiogenesis to assess how geometry affects vascular patterning and compares results to planar models.

This study models how tumour oxygen levels change during radiotherapy and shows how oxygen heterogeneity affects radiation response and treatment outcomes.