H. Gerhardt

Mechanical Strain Activates Planar Cell Polarity Signaling to Coordinate Vascular Cell Dynamics

This study identifies Vangl1 as a key mediator of flow-dependent cell dynamics in vascular remodeling through planar cell polarity signaling.

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

The paper identifies LGALS1 as an immunomodulating target in glioblastoma by analyzing GAM-GBM interactions using single-cell RNA sequencing and zebrafish models.

Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth

The paper identifies a novel endothelial cell population in tumors that contributes to vascularization and growth.

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling

This paper presents an agent-based model to study how endothelial cells integrate flow and collective cues to preserve vessel bifurcations during angiogenic remodelling, finding that both cues must be balanced for stability.

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy

This study identifies PKA-mediated phosphorylation of ATG16L1 as a mechanism to limit autophagy and regulate angiogenesis in endothelial cells.

Arterio-Venous Remodeling in the Zebrafish Trunk Is Controlled by Genetic Programming and Flow-Mediated Fine-Tuning

The paper shows that zebrafish trunk vasculature balance is controlled by early genetic programming and flow-mediated adjustments.