M. P. Foster

Insights into Ligand-Mediated Activation of an Oligomeric Ring-Shaped Gene-Regulatory Protein from Solution- and Solid-State NMR

This study uses NMR techniques to investigate the structural and dynamic changes in TRAP upon Trp binding, revealing a mechanism for cooperative ligand binding.

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.

Thermodynamic coupling between neighboring binding sites in homo-oligomeric ligand sensing proteins from mass resolved ligand dependent population distributions

The paper quantifies thermodynamic coupling between ligand binding sites in homo-oligomeric proteins using statistical models and native mass spectrometry, revealing large differences in cooperativity.

Nearest-neighbor effects modulate loxP spacer DNA chemical shifts and guide oligonucleotide design for NMR studies

The paper identifies a 16-bp loxP spacer oligonucleotide that preserves structural features for NMR studies, revealing nearest-neighbor effects dominate chemical shifts.