Cancer BiologybioRxiv
Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
DOI 10.1016/j.celrep.2023.112538
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3 papers
Recent·Most cited
M. Paes Dias, V. Tripathi, I. v. d. Heijden…·J. Jonkers
This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.
C. Lo, M. van Toorn, V. Gaggioli…·N. Taneja
This study identifies SMARCAD1 as a critical factor for replication fork stability, showing its role in preventing genome instability and enhancing resistance to replication poisons.