Cancer BiologybioRxivPreprint
Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps
M. Paes Dias, V. Tripathi, I. v. d. Heijden…·J. Jonkers
This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.
DOI 10.1101/2021.03.24.436323