Molecular basis of F-actin regulation and sarcomere assembly via myotilin
J. Kostan, M. Pavsic, V. Puz, T. C. Schwarz, F. Drepper, S. Molt, M. A. Graewert, C. Schreiner, S. Sajko, P. F. M. van der Ven, D. Svergun, B. Warscheid, R. Konrat, D. O. Fuerst, B. Lenarcic, K. Djinovic-Carugo
This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.
bioRxiv · Sep 25, 2020Biochemistry