Author

J. Kostan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

K. Djinovic-Carugo· 3 shared S. Sajko· 2 shared A. Sponga· 1 shared A.-C. Gavin· 1 shared B. C. Morriswood· 1 shared B. Lenarcic· 1 shared B. Warscheid· 1 shared C. Gehin· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

K. Djinovic-Carugo

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3 papers

Recent·Most cited

Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C

M. Nagy, G. Mlynek, J. Kostan, L. Smith, D. Puehringe, P. Charron, T. B. Rasmussen, Z. Bilinska, M. M. Akhtar, P. Syrris, L. R. Lopes, P. M. Elliott, M. Gautel, O. Carugo, K. Djinovic-Carugo

The paper develops a machine learning model to predict the impact of missense variants in human filamin C, achieving high accuracy in distinguishing pathogenic from non-pathogenic variants.

bioRxiv · Aug 5, 2023 · PreprintBiophysics

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

J. Kostan, M. Pavsic, V. Puz, T. C. Schwarz, F. Drepper, S. Molt, M. A. Graewert, C. Schreiner, S. Sajko, P. F. M. van der Ven, D. Svergun, B. Warscheid, R. Konrat, D. O. Fuerst, B. Lenarcic, K. Djinovic-Carugo

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

bioRxiv · Sep 25, 2020Biochemistry

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

S. Sajko, I. Grishkovskaya, J. Kostan, M. Graewert, K. Setiawan, L. Truebestein, K. Niedermuller, C. Gehin, A. Sponga, M. Puchinger, A.-C. Gavin, T. Leonard, D. I. Svergun, T. K. Smith, B. C. Morriswood, K. Djinovic-Carugo

This study investigates MORN repeat proteins, revealing they are protein-protein interaction modules rather than lipid-binding modules, based on structural and functional analyses of TbMORN1 and homologs.

bioRxiv · Jun 23, 2020Biochemistry