Author

R. Konrat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. D. Gossert· 1 shared A. Kuczmog· 1 shared A. Löbbert· 1 shared B. Cossins· 1 shared B. Lenarcic· 1 shared B. Shrestha· 1 shared B. Warscheid· 1 shared C. Schreiner· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperBiophysics

A. D. Gossert

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Human Cells for Human Proteins: Isotope Labeling in Mammalian Cells for Functional NMR Studies of Disease-Relevant Proteins

P. Rössler, M. Ruckstuhl, A. Löbbert, T. Stühlinger, L. R. Franchini, C.-J. Tsai, R. Lichtenecker, B. Shrestha, S. H. Rüdisser, R. Konrat, G. F. X. Schertler, A. D. Gossert

The paper develops cost-effective isotope labeling protocols in HEK293 cells for NMR studies of difficult-to-produce human proteins, enabling detailed structural and functional analysis.

bioRxiv · Apr 9, 2024Biophysics

Inverse PI by NMR: Analysis of Ligand 1H-Chemical Shifts in the Protein-Bound State

G. Platzer, M. Mayer, J. Boettcher, L. Geist, J. E. Fuchs, D. B. McConnell, R. Konrat

The paper analyzes ligand 1H chemical shifts in the protein-bound state using NMR to study protein-ligand interactions and their conformational and solvation effects.

bioRxiv · Nov 30, 2021Biophysics

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

J. Kostan, M. Pavsic, V. Puz, T. C. Schwarz, F. Drepper, S. Molt, M. A. Graewert, C. Schreiner, S. Sajko, P. F. M. van der Ven, D. Svergun, B. Warscheid, R. Konrat, D. O. Fuerst, B. Lenarcic, K. Djinovic-Carugo

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

bioRxiv · Sep 25, 2020Biochemistry

The Anti-histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits SARS-CoV-2 Infection in Reconstituted Human Nasal Tissue In Vitro

R. Konrat, H. Papp, V. Szijarto, T. Gesell, G. Nagy, M. Madai, S. Zeghbib, A. Kuczmog, Z. Lanszki, Z. Helyes, G. Kemenesi, F. Jakab, E. Nagy

This paper identifies azelastine, an anti-histamine drug, as a potential inhibitor of SARS-CoV-2 infection through computational repurposing and in vitro testing in human nasal tissue.

bioRxiv · Sep 15, 2020 · PreprintMicrobiology

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR

S.-B. Amos, T. Schwarz, J. Shih, B. Cossins, T. Baker, R. Taylor, R. Konrat, M. Sansom

This study uses multiscale simulations and NMR to reveal structural changes in α-synuclein bound to lipid bilayers, providing insights into its role in Parkinson's disease.

bioRxiv · Jun 18, 2020Biophysics