Author

M. A. Graewert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Lawson· 1 shared A. Macpherson· 1 shared B. D. Geronimo· 1 shared B. Holmes· 1 shared B. Lenarcic· 1 shared B. Warscheid· 1 shared C. Buhlheller· 1 shared C. M. Deane· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

A. Lawson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Vibrio cholerae's ToxRS Bile Sensing System

N. Gubensaek, T. Sagmeister, C. Buhlheller, B. D. Geronimo, G. E. Wagner, L. Petrowitsch, M. A. Graewert, M. Rotzinger, T. I. Berger, J. Schäfer, I. Uson, J. Reidl, P. A. Sanchez-Murcia, K. Zangger, T. Pavkov-Keller

This study reveals the crystal structure of ToxRS and its interaction with bile acids, showing ToxS's folded bile-binding pocket depends on ToxR and highlighting its conservation across Vibrio species.

bioRxiv · May 2, 2023Biochemistry

The allosteric modulation of Complement C5 by knob domain peptides

A. Macpherson, M. Laabei, Z. Ahdash, M. A. Graewert, J. Birtley, S. Schulze, S. Crennell, S. Robinson, B. Holmes, V. Oleinikovas, P. H. Nilsson, J. Snowden, V. Ellis, T. E. Mollnes, C. M. Deane, , J. van den Elsen

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

bioRxiv · Oct 24, 2020Immunology

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

J. Kostan, M. Pavsic, V. Puz, T. C. Schwarz, F. Drepper, S. Molt, M. A. Graewert, C. Schreiner, S. Sajko, P. F. M. van der Ven, D. Svergun, B. Warscheid, R. Konrat, D. O. Fuerst, B. Lenarcic, K. Djinovic-Carugo

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

bioRxiv · Sep 25, 2020Biochemistry