Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia
A. Bradshaw, E. Low, J. T. Schwartze, A. Kurkiewicz, M. Pek, D. Kelly, A. Shaw, M. Thorikay, J. McClure, M. McBride, S. Arias-Rivas, S. E. Francis, N. Morrell, C. Delles, P. Herzyk, , A. H. Baker
This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.
bioRxiv · Nov 29, 2019 · PreprintCell Biology