D. Kelly

Leaf abaxial and adaxial surfaces differentially affect plant-fungal pathogen interactions

The paper investigates how Botrytis cinerea interacts with abaxial and adaxial leaf surfaces across multiple plant species, finding that abaxial surfaces are more susceptible and linking this to defense signaling and compound production.

Melt electrowritten scaffold architectures to mimic vasculature mechanics and control neo-tissue orientation

This study uses melt-electrowriting to create scaffolds mimicking vascular mechanics, showing they support cell alignment and neo-tissue orientation similar to native vessels.

In-situ quality monitoring during embedded bioprinting using integrated microscopy and classical computer vision

This paper develops a bioprinting platform with integrated microscopy and computer vision for real-time quality monitoring, showing that hydrogel rheology affects print fidelity.

Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth.

This study delivers miR-29b via nanoparticles to treat osteosarcoma, reducing tumour burden and improving bone homeostasis when combined with chemotherapy.

Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy

This study identifies metabolic and proteomic defects in human hypertrophic cardiomyopathy, showing depletion of fatty acid derivatives and increased alternate fuel metabolites.

STING Nuclear Partners Contribute to Innate Immune Signalling Responses

The paper identifies nuclear STING partners that contribute to innate immune signaling by interacting with IRF3/7 transcription factors and enhancing antiviral responses.

Connexin 43 confers chemoresistance through activating PI3K

This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.

Analysis of pluripotency transcription factor interactions reveals preferential binding of NANOG to SOX2 rather than NANOG or OCT4

This study investigates the interactions of pluripotency transcription factors Nanog, Sox2, and Oct4, revealing Nanog's preferential binding to Sox2 over Oct4 and its ability to form homomultimers.

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.