Author

M. Pennuto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Astolfi· 1 shared A. Boldrini· 1 shared A. Falconieri· 1 shared A. Ianeselli· 1 shared B. Vignoli· 1 shared D. Gasparotto· 1 shared D. Piovesan· 1 shared E. Biasini· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Astolfi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor

A. Falconieri, G. Minervini, R. Bortolotto, D. Piovesan, R. Lopreiato, G. Sartori, M. Pennuto, S. C. E. Tosatto

This study identifies a novel interaction between pVHL30 and MDM2, showing isoform-specific binding and functional synergy in cell proliferation regulation.

bioRxiv · Apr 28, 2020Biochemistry

PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES

G. Spagnolli, T. Massignan, A. Astolfi, S. Biggi, P. Brunelli, M. Libergoli, A. Ianeselli, S. Orioli, A. Boldrini, L. Terruzzi, G. Maietta, M. Rigoli, N. Lopez Lorenzo, L. C. Fernandez, L. Tosatto, , E. Biasini

The paper discovers non-native metastable states in protein folding pathways and develops a novel drug discovery approach, PPI-FIT, to target these intermediates to lower protein expression.

bioRxiv · Mar 31, 2020 · PreprintBiochemistry