Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon
R. R. Sevalkar, J. N. Glasgow, M. Pettinati, M. A. Martin, V. P. Reddy, S. Basu, E. Alipour, D. B. Kim-Shapiro, D. A. Estrin, J. R. Lancaster, A. J. Steyn
This study shows Mycobacterium tuberculosis uses its DosS sensor kinase to detect H2S via Fe3+ heme binding, activating the dormancy regulon.
bioRxiv · Jun 21, 2021 · PreprintBiochemistry