Author

J. N. Glasgow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. J. Steyn· 4 shared K. Lumamba· 3 shared k. Nargan· 3 shared R. R. Sevalkar· 3 shared T. Naidoo· 3 shared J. R. Lancaster· 2 shared R. L. Hunter· 2 shared S. Nadeem· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

A. J. Steyn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Detection of Mycobacterium tuberculosis in human tissue via RNA in situ hybridization

k. Nargan, T. Naidoo, M. Msimang, S. Nadeem, G. Wells, R. L. Hunter, A. Hutton, K. Lumamba, J. N. Glasgow, P. V. Benson, A. J. Steyn

This paper uses RNA in situ hybridization to detect Mycobacterium tuberculosis mRNA in human tissue, identifying Mtb in ZN-negative samples and revealing two distinct Mtb populations.

bioRxiv · Oct 4, 2023 · PreprintMicrobiology

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

H. T. Pacl, K. C. Chinta, V. P. Reddy, S. Nadeem, R. R. Sevalkar, K. Nargan, K. Lumamba, T. Naidoo, J. N. Glasgow, A. Agarwal, A. J. C. Steyn

This study shows that NAD(H) homeostasis in glycolytic myeloid cells is critical for host protection against tuberculosis, with nicotinamide reducing Mtb lung burden.

bioRxiv · Sep 11, 2022 · PreprintMicrobiology

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon

R. R. Sevalkar, J. N. Glasgow, M. Pettinati, M. A. Martin, V. P. Reddy, S. Basu, E. Alipour, D. B. Kim-Shapiro, D. A. Estrin, J. R. Lancaster, A. J. Steyn

This study shows Mycobacterium tuberculosis uses its DosS sensor kinase to detect H2S via Fe3+ heme binding, activating the dormancy regulon.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Mycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility

T. T. R. Kunota, M. A. Rahman, B. E. Truebody, J. S. Mackenzie, V. Saini, D. A. Lamprecht, J. H. Adamson, R. R. Sevalkar, J. R. Lancaster, M. Berney, J. N. Glasgow, A. J. Steyn

This study identifies H2S as an endogenous molecule in M. tuberculosis that modulates metabolism, bioenergetics, and drug susceptibility.

bioRxiv · Jun 2, 2021Microbiology

3D microarchitecture of the human tuberculous granuloma

G. A. Wells, J. N. Glasgow, K. Nargan, K. Lumamba, R. Madansein, K. Maharaj, R. L. Hunter, T. Naidoo, P. Ramdial, L. Coetzer, S. le Roux, A. du Plessis, A. J. Steyn

This study uses 3D X-ray imaging to reveal complex, branched structures of human tuberculous granulomas, challenging the traditional view of spherical granulomas and suggesting implications for TB treatment strategies.

bioRxiv · Jun 14, 2020 · PreprintMicrobiology