M. R. Birtwistle

This paper introduces a theory for high-throughput genetic interaction screening using spectrally unique barcodes from fluorescent proteins, enabling genome-scale genetic perturbation studies.

The paper introduces Mesowestern blot, a high-throughput Western blotting method using 3D-printable gels to analyze small sample volumes with standard protocols.

The paper introduces a method to label antibodies with MuSIC probes for fluorescent multiplexing, validated through spectral flow cytometry.

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

This paper introduces MuSIC, a method for fluorescence multiplexing using spectral imaging and combinatorics, achieving ~4-5 fold increase in multiplexing with existing dyes and tools.

This paper validates antibodies for quantitative western blotting using microwestern arrays, finding many antibodies suitable for quantitative use and demonstrating scalability to standard western blots.