R. Iyengar

Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice

This study shows that muscle-specific Nox4 knockout in mice improves muscle contractility after spinal cord injury, though force remains lower than in uninjured controls.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

Cell shape regulates subcellular organelle location to control short-term Ca2+ signal dynamics in vascular smooth muscle cells

The paper shows how cell shape changes affect subcellular organelle positioning, altering Ca2+ signaling and phenotypic function in vascular smooth muscle cells.

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

Geometric principles of second messenger dynamics in dendritic spines

This study uses mathematical modeling to show how spine and spine apparatus geometry affects second messenger dynamics in dendritic spines.

Whole cell response to receptor stimulation involves many deep and distributed subcellular processes

The paper identifies subcellular processes involved in cannabinoid-1 receptor regulated neurite outgrowth and shows they are distributed and deep.

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array

This paper validates antibodies for quantitative western blotting using microwestern arrays, finding many antibodies suitable for quantitative use and demonstrating scalability to standard western blots.