Author

M. R. Googins

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Biochemistry· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. O. Woghiren-Afegbua· 1 shared A. P. VanDemark· 1 shared K. Kiselyov· 1 shared M. R. Brown· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

A. O. Woghiren-Afegbua

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1 paper

Recent·Most cited

GDAP1 binds 4-hydroxynonenal, the toxic end-product of lipid peroxidation, using its GST-like binding pocket

M. R. Googins, M. R. Brown, A. O. Woghiren-Afegbua, K. Kiselyov, A. P. VanDemark

This study identifies 4-hydroxynonenal as the ligand for GDAP1, showing its binding requires a unique -loop and that mutations affecting this loop impair 4HNE binding and contribute to CMT disease.

bioRxiv · Oct 28, 2022 · PreprintBiochemistry