GDAP1 binds 4-hydroxynonenal, the toxic end-product of lipid peroxidation, using its GST-like binding pocket
M. R. Googins, M. R. Brown, A. O. Woghiren-Afegbua, K. Kiselyov, A. P. VanDemark
This study identifies 4-hydroxynonenal as the ligand for GDAP1, showing its binding requires a unique -loop and that mutations affecting this loop impair 4HNE binding and contribute to CMT disease.
bioRxiv · Oct 28, 2022 · PreprintBiochemistry