Author

K. Kiselyov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Gopalkrishnan· 2 shared A. Yassin-Kassab· 2 shared M. R. Brown· 2 shared S. Cruz-Rangel· 2 shared A. Kowalczyk· 1 shared A. O. Woghiren-Afegbua· 1 shared A. P. VanDemark· 1 shared C. A. Bertrand· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

A. Gopalkrishnan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lysosomal mitochondrial interaction promotes tumor growth in squamous cell carcinoma of the head and neck

A. Gopalkrishnan, N. Wang, S. Cruz-Rangel, A. Yassin-Kassab, S. Shiva, C. Kurukulasuriya, S. P. Monga, R. J. DeBerardinis, K. Kiselyov, U. Duvvuri

This study shows that lysosomal-mitochondrial interaction (LMI) promotes tumor growth in squamous cell carcinoma of the head and neck by enhancing mitochondrial complex I activity and lysosomal function.

bioRxiv · Jun 25, 2023Cancer Biology

Missense mutations in the calcium-activated chloride channel TMEM16A promote tumor growth by activating oncogenic signaling in Human Cancer.

S. Cruz-Rangel, J. J. De Jesus-Perez, A. Gopalkrishnan, R. Gomez-Casal, J. Pacheco, M. R. Brown, A. Yassin-Kassab, G. R. Hammond, C. A. Bertrand, J. Arreola, K. Kiselyov, D. Umamaheswar

This paper investigates TMEM16A missense mutations in cancer, finding they promote tumor growth through altered signaling, independent of chloride flux.

bioRxiv · Jun 21, 2023 · PreprintCancer Biology

Impairment of autophagy-lysosomal activity near the chronically implanted microelectrodes

K. Chen, C. Garcia, K. Kiselyov, T. D. Y. Kozai

This study investigates how long-term microelectrode implantation impairs autophagy-lysosomal activity, leading to tissue degeneration near the implant.

bioRxiv · May 31, 2023 · PreprintBioengineering

GDAP1 binds 4-hydroxynonenal, the toxic end-product of lipid peroxidation, using its GST-like binding pocket

M. R. Googins, M. R. Brown, A. O. Woghiren-Afegbua, K. Kiselyov, A. P. VanDemark

This study identifies 4-hydroxynonenal as the ligand for GDAP1, showing its binding requires a unique -loop and that mutations affecting this loop impair 4HNE binding and contribute to CMT disease.

bioRxiv · Oct 28, 2022 · PreprintBiochemistry

Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter.

A. Kowalczyk, O. Gbadamosi, K. Kolor, J. Sosa, C. St Croix, G. Gibson, M. Chikina, E. Aizenman, N. Clark, K. Kiselyov

The paper uses evolutionary rate covariation to predict the mitochondrial localization of SLC30A9, which is confirmed experimentally as a zinc exporter.

bioRxiv · Apr 22, 2021Evolutionary Biology