Author

M. R. Mangalea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

B. A. Duerkop· 3 shared A. Chatterjee· 2 shared B. R. Borlee· 2 shared A. Sakatos· 1 shared B. A. Plumley· 1 shared B. D. McCollister· 1 shared C. N. Johnson· 1 shared D. P. Araya· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

B. A. Duerkop

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Author profile →

5 papers

Recent·Most cited

Disruption of c-di-GMP signaling networks unlocks cryptic expression of secondary metabolites during biofilm growth in Burkholderia pseudomallei

G. I. Borlee, M. R. Mangalea, K. H. Martin, B. A. Plumley, S. J. Golon, B. R. Borlee

This study disrupts c-di-GMP signaling in Burkholderia pseudomallei to uncover how it regulates secondary metabolite expression during biofilm growth, revealing temperature-dependent gene regulation and biofilm-related phenotypes.

bioRxiv · Dec 12, 2021Microbiology

Genetically distant bacteriophages elicit unique genomic changes in Enterococcus faecalis

C. N. Johnson, D. P. Araya, V. Schink, M. Islam, M. R. Mangalea, E. K. Decurtis, T.-V. C. Ngo, K. L. Palmer, B. A. Duerkop

This study shows that genetically distinct bacteriophages induce unique genomic changes in Enterococcus faecalis, highlighting phage-specific host responses during evolution.

bioRxiv · Oct 28, 2021 · PreprintMicrobiology

Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

M. R. Mangalea, D. Paez-Espino, K. A. Kieft, A. Chatterjee, J. A. Seifert, M. L. Feser, M. K. Demoruelle, M. E. Chriswell, A. Sakatos, K. Anantharaman, K. D. Deane, K. A. Kuhn, V. M. Holers, B. A. Duerkop

The paper identifies differential intestinal bacteriophage communities in individuals at risk for RA based on anti-CCP status, linking them to distinct metabolic potentials and potential roles in RA pathogenesis.

bioRxiv · Feb 3, 2021Microbiology

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

G. S. Canfield, A. Chatterjee, J. Espinosa, M. R. Mangalea, E. K. Sheriff, M. Keidan, S. W. McBride, B. D. McCollister, H. C. Hang, B. A. Duerkop

This study identifies cell wall-associated molecules that confer phage resistance in E. faecium and shows that phage resistance mutations enhance antibiotic susceptibility and synergize with antimicrobials.

bioRxiv · Sep 22, 2020Microbiology

The NarX-NarL two-component system is a global regulator of biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei

B. R. Borlee, M. R. Mangalea

This study identifies the NarX-NarL two-component system as a regulator of biofilm formation, natural product biosynthesis, and host survival in B. pseudomallei through transcriptomic analysis.

bioRxiv · Jun 25, 2020 · PreprintMicrobiology