Author

H. C. Hang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 6 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Assay:metagenomics· 2

Frequent Co-Authors

M. E. Griffin· 5 shared J. Espinosa· 2 shared V. Chen· 2 shared A. Chatterjee· 1 shared A. M. Keestra-Gounde· 1 shared A. Mehmood· 1 shared A. Percher· 1 shared A. Shen· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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5 shared papersCancer Biology

M. E. Griffin

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor cancer therapy

S. Klupt, K. T. Fam, X. Zhang, P. K. Chodisetti, A. Mehmood, T. Boyd, D. Grotjahn, D. Park, H. C. Hang

This study identifies SagA as essential for E. faecium growth, cell separation, and immune checkpoint inhibitor cancer therapy, showing its role in muropeptide production and NOD2 activation.

bioRxiv · Nov 19, 2023Microbiology

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

K. K. Jang, T. Heaney, M. London, Y. Ding, F. Yeung, D. Ercelen, Y.-H. Chen, J. Axelrad, S. Gurunathan, A. M. Keestra-Gounde, M. E. Griffin, H. C. Hang, K. Cadwell

The paper shows that overproduction of REG3 proteins in IBD flares reduces Enterococcus faecium, worsening inflammation by disrupting microbiota-immune interactions.

bioRxiv · Jan 29, 2023 · PreprintImmunology

N-arylpyrazole NOD2 agonists promote immune checkpoint inhibitor therapy

M. E. Griffin, T. Tsukidate, H. C. Hang

This study develops N-arylpyrazole NOD2 agonists that enhance immune checkpoint inhibitor therapy by specifically activating NOD2.

bioRxiv · Jan 26, 2023 · PreprintCancer Biology

Identification of a bile acid-binding transcription factor in Clostridioides difficile using chemical proteomics

E. R. Forster, X. Yang, H. C. Hang, A. Shen

This study identifies BapR, a bile acid-sensing transcription factor in C. difficile, using chemical proteomics and shows it regulates gene expression in response to lithocholic acid.

bioRxiv · May 26, 2022Microbiology

Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A

X. Zhao, K. R. Stein, V. Chen, M. E. Griffin, H. C. Hang

The paper identifies small-molecule agonists for the orphan receptor GPRC5A using chemoproteomics of microbiota metabolites, revealing bacterial sources and key residues involved in ligand binding.

bioRxiv · Dec 16, 2021 · PreprintBiochemistry

Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium

G. S. Canfield, A. Chatterjee, J. Espinosa, M. R. Mangalea, E. K. Sheriff, M. Keidan, S. W. McBride, B. D. McCollister, H. C. Hang, B. A. Duerkop

This study identifies cell wall-associated molecules that confer phage resistance in E. faecium and shows that phage resistance mutations enhance antibiotic susceptibility and synergize with antimicrobials.

bioRxiv · Sep 22, 2020Microbiology

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

E. H. Garst, H. Lee, T. Das, S. Bhattacharya, A. Percher, R. Wiewiora, I. P. Witte, Y. Li, M. Goger, T. Peng, W. Im, H. C. Hang

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

bioRxiv · Sep 11, 2020Biochemistry

RecT recombinase expression enables efficient gene editing in Enterococcus

V. Chen, M. E. Griffin, H. C. Hang

This paper demonstrates that expressing RecT recombinase in Enterococcus species significantly improves gene editing efficiency using recombineering techniques.

bioRxiv · Sep 1, 2020Microbiology

Enterococcus peptidoglycan remodeling promotes immune checkpoint inhibitor therapy

M. E. Griffin, J. Espinosa, J. L. Becker, J. K. Jha, G. R. Fanger, H. C. Hang

The paper shows that Enterococcus species enhance immune checkpoint inhibitor therapy by remodeling peptidoglycan and activating Nod2.

bioRxiv · Aug 20, 2020Cancer Biology