Author

V. M. Holers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Filer· 2 shared C. Pitzalis· 2 shared D. A. Rao· 2 shared D. L. Boyle· 2 shared D. Tabechian· 2 shared F. Zhang· 2 shared G. S. Firestein· 2 shared K. A. Kuhn· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. Filer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

G. S. Dunlap, A. Wagner, N. Meednu, F. Zhang, A. H. Jonsson, K. Wei, S. Sakaue, A. Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (A, V. P. Bykerk, L. T. Donlin, S. M. Goodman, G. S. Firestein, D. L. Boyle, V. M. Holers, , J. Anolik

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Dual IgA/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

M. Chriswell, A. R. Lefferts, M. Clay, A. Hsu, J. Seifert, M. L. Feser, M. Maerz, C. Rims, M. Bloom, E. A. Bemis, M. K. Demoruelle, K. D. Deane, E. A. James, J. H. Buckner, W. H. Robinson, , K. A. Kuhn

Subdoligranulum spp. targeted by RA-relevant autoantibodies activate T cells in RA patients and induce autoantibodies and joint swelling in mice.

bioRxiv · Jun 9, 2022 · PreprintImmunology

Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

M. R. Mangalea, D. Paez-Espino, K. A. Kieft, A. Chatterjee, J. A. Seifert, M. L. Feser, M. K. Demoruelle, M. E. Chriswell, A. Sakatos, K. Anantharaman, K. D. Deane, K. A. Kuhn, V. M. Holers, B. A. Duerkop

The paper identifies differential intestinal bacteriophage communities in individuals at risk for RA based on anti-CCP status, linking them to distinct metabolic potentials and potential roles in RA pathogenesis.

bioRxiv · Feb 3, 2021Microbiology

Insights into the role of C3d dimers in B cell activation and Staphylococcal immune evasion

A. A. Wahid, R. W. Dunphy, A. Macpherson, B. G. Gibson, L. Kulik, K. Whale, C. R. Back, T. M. Hallam, B. Alkhawaja, R. L. Martin, I. P. Meschede, A. D. G. Lawson, V. M. Holers, A. G. Watts, S. J. Crennell, , J. M. H. van den Elsen

This study identifies C3d dimers' role in B cell activation and their potential to promote anergy, contributing to Staphylococcus aureus immune evasion and autoimmunity.

bioRxiv · Apr 22, 2020 · PreprintImmunology

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, D. A. Rao, S. Kelly, S. M. Goodman, D. Tabechian, L. B. Hughes, K. Salomon-Escoto, G. F. M. Watts, W. Apruzzese, D. J. Lieb, D. L. Boyle, A. M. Mandelin, , S. Raychaudhuri

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

bioRxiv · Jun 20, 2018Immunology