Inhibition of tryptophan-2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
M. R. Reed, L. Maddukuri, A. Ketkar, S. D. Byrum, M. K. Zafar, A. C. L. Bostian, A. J. Tackett, R. L. Eoff
This study shows that inhibiting TDO in glioma cells impairs DNA repair and increases sensitivity to DNA-damaging agents.
bioRxiv · May 28, 2020Cancer Biology