Author

A. J. Tackett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

I. R. Miousse· 2 shared K. F. Wallis· 2 shared A. C. L. Bostian· 1 shared A. J. Gies· 1 shared A. Ketkar· 1 shared E. R. Siegel· 1 shared J. T. Bird· 1 shared L. C. Morehead· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

I. R. Miousse

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Author profile →

3 papers

Recent·Most cited

Increased response to immune checkpoint inhibitors with dietary methionine restriction

L. C. Morehead, S. Garg, K. F. Wallis, E. R. Siegel, A. J. Tackett, I. R. Miousse

This study shows that dietary methionine restriction enhances immune checkpoint inhibitor efficacy in mice by increasing MHC-I and PD-L1 expression via the cGAS-STING pathway and interferon signaling.

bioRxiv · Apr 5, 2023 · PreprintCancer Biology

Methionine stress induces a ferroptotic gene signature in methionine dependent cancer cells

K. F. Wallis, J. T. Bird, A. J. Gies, S. G. Mackintosh, A. J. Tackett, S. Byrum, I. R. Miousse

The paper shows that methionine stress induces a ferroptotic gene signature in methionine-dependent cancer cells, which is reduced in methionine-independent cells.

bioRxiv · Aug 18, 2020 · PreprintCancer Biology

Inhibition of tryptophan-2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells

M. R. Reed, L. Maddukuri, A. Ketkar, S. D. Byrum, M. K. Zafar, A. C. L. Bostian, A. J. Tackett, R. L. Eoff

This study shows that inhibiting TDO in glioma cells impairs DNA repair and increases sensitivity to DNA-damaging agents.

bioRxiv · May 28, 2020Cancer Biology