BiochemistrybioRxiv
Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein
C. Kampmeyer, S. Larsen-Ledet, M. R. Wagnkilde…·R. Hartmann-Petersen
The paper identifies two PQC degrons in DHFR that become exposed in disease-linked missense variants, leading to proteasomal degradation.
DOI 10.1016/j.str.2022.05.016