Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein
C. Kampmeyer, S. Larsen-Ledet, M. R. Wagnkilde, M. Michelsen, H. K. M. Iversen, S. V. Nielsen, S. Lindemose, A. Caregnato, T. Ravid, A. Stein, K. Teilum, K. Lindorff-Larsen, R. Hartmann-Petersen
The paper identifies two PQC degrons in DHFR that become exposed in disease-linked missense variants, leading to proteasomal degradation.
bioRxiv · Nov 4, 2021Biochemistry