Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice
E. A. Wynn, C. Dide-Agossou, M. Reichlen, K. Rossmassler, R. Al Mubarak, J. J. Reid, S. T. Tabor, S. E. Born, M. R. Ransom, R. M. Davidson, K. N. Walton, J. B. Benoit, A. Hoppers, A. A. Bauman, L. M. Massoudi, , N. D. Walter
This study develops a targeted amplification RNA sequencing method, SEARCH-TB, to analyze Mycobacterium tuberculosis transcriptomes in mice during treatment, revealing transcriptional adaptations including metabolic shifts and regulatory reprogramming.
bioRxiv · Mar 6, 2023Microbiology